Treatments for Dravet Syndrome Seizures
Dravet syndrome is a rare form of epilepsy that begins in infancy and causes frequent and severe seizures. These seizures can be difficult to control, but there are treatment options available like FINTEPLA, a prescription medication approved to treat seizures associated with Dravet syndrome.
1. FINTEPLA (Fenfluramine)
FINTEPLA is an oral solution that works by affecting the levels of serotonin in the brain, which helps control seizures. Clinical studies have shown that FINTEPLA can significantly reduce the frequency of seizures in children and adults with Dravet syndrome. It’s often used in combination with other medications to improve its effectiveness.
2. Clobazam
Clobazam is an anticonvulsant medication often prescribed to people with Dravet syndrome. It is usually used as an add-on therapy for patients who are not fully controlled with other medications. Clobazam can help reduce the frequency and intensity of seizures by stabilizing electrical activity in the brain. It works by enhancing the effects of a neurotransmitter called GABA, which helps prevent seizures.
3. Valproate
Valproate, also known as valproic acid, is another anticonvulsant that has been commonly used in the treatment of Dravet syndrome. It works by increasing the levels of GABA in the brain, similar to clobazam. Although effective for many people, valproate may not be suitable for everyone, especially young children, due to its potential side effects.
4. Stiripentol
Stiripentol is a medication specifically approved for use in Dravet syndrome, especially when other treatments haven’t worked. It is often used in combination with clobazam and valproate to improve seizure control. Stiripentol works by enhancing the action of GABA and also affects the body’s ability to process certain chemicals that play a role in seizure activity.
5. Ketogenic Diet
In some cases, doctors recommend a ketogenic diet for people with Dravet syndrome. This high-fat, low-carbohydrate diet can help reduce seizures by changing the way the brain uses energy. The ketogenic diet has been shown to be effective for some children with Dravet syndrome, although it requires close monitoring by a healthcare provider to ensure it’s being followed safely.
6. Vagus Nerve Stimulation (VNS)
Vagus nerve stimulation (VNS) is a treatment option for children and adults with drug-resistant seizures. A small device is implanted under the skin near the chest, and it sends electrical pulses to the vagus nerve, which then helps regulate brain activity. This treatment can be particularly helpful for people whose seizures do not respond to medications alone.
7. Other Anticonvulsants
There are several other anticonvulsant medications that may be prescribed for people with Dravet syndrome, including topiramate, levetiracetam and lamotrigine. These medications may be used alone or in combination with other treatments to help manage seizures.
Treatment Solutions That Work
Managing seizures in Dravet syndrome requires a comprehensive approach, often involving a combination of medications and therapies. FINTEPLA has emerged as a leading option for controlling seizures, and when used in combination with other treatments, it can make a significant difference in the quality of life for those affected.
It’s important for individuals with Dravet syndrome to work closely with their healthcare provider to find the best treatment plan for their specific needs. Regular follow-up appointments and adjustments to medication can help achieve better seizure control and improve overall well-being.